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KMID : 0861020040190010013
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Korea Journal of Herbology
2004 Volume.19 No. 1 p.13 ~ p.21
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The Effects of Angelicae Gigantis Radix, Angelicae Acutilobae Radix and Angelicae Sinensis Radix Extract on Hydrocortisone Acetate-Induced Model of Blood Stasis
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송승현/Song, Seung-Hyun
서부일/김호경/박지하/Seo, Bu-Il/Kim, Ho-Kyoung/Park, Ji-Ha
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Abstract
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Objectives : This study was performed to compare the effect of Angelicae Gigantis Radix, Angelicae Acutilobae Radix and Angelicae Sinensis Radix extract on model of blood stasis in rats.
Methods : Except for the normal group, hydrocortisone acetate(HA;%mg/kg in ethanol, IM) was injected to induce experimental blood stasis model for 1 weeks and each extract was administrated after lhr following HA injection for lweek. We measured the hematocrit, the platelet count, the prothrombin time, levels of fibrinogen and RBC counts in rat s blood.
Results : Angelicae Gigantis Radix, Angelicae Acutilobae Radix group showed significant increase of hematocrit in comparison with that of the control group. Angelicae Gigantis Radix, Angelicae Acutilobae Radix and Angelicae Sinensis Radix group showed significant increase of the platelet count in comparison with that of the control group. Angelicae Gigantis Radix group showed significant decrease of prothrombin time in comparison with that of the control group. Angelicae Gigantis Radix, Angelicae Acutilobae Radix and Angelicae Sinensis Radix group showed significant increase of fibrinogen in comparison with that of the control group. Angelicae Sinensis Radix group showed significant decrease of RBC counts in comparison with that of the control group.
Conclusions : Reviewing these experimental results, it appears that Angelicae Gigantis Radix, Angelicae Acutilobae Radix and Angelicae Sinensis Radix have similar pharmaceutical efficacy on model of blood stasis. In particular Angelicae Gigantis Radix showed good efficacy in comparison with Angelicae Acutilobae Radix and Angelicae Sinensis Radix. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.
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